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Abstract. The skills of the 21st century are expected to be solution in the face of industrial revolution 4.0 this skill comes after students gain an education. So to confront such matters, required an innovative learning system corresponding with the advancement technology. It is therefore expected that STEM-based learning can be a solution in face of these challenges. This research aims to develop practical design based STEM learning colloidal designed to build students science literacy through the creation of probiotic ice cream leather waste from pineapple. Research methods used namely refers to a development model Thiagaran 4-D (Define, Design, Develop, Diseminate) but this only used in research to develop. The definition phase is carried out preliminary studies to know the use method teaching in schools General, stage design was done designing learning devices form of implementation plan Learning and worksheet. Participants in this research were 20 students of Class XI. Data analysis was carried out by calculating percentage and the results were interpreted to determine the validity and feasibility of the practicum design developed. The results of the study stated that the practicum design developed was feasible to be applied to learning for students of Class XI on Colloidal material.