Mangrove Plant Leaf Potential Weeds (Acanthus Ilicifolius) As Antidiabetic
Elmiawati Latifah (a)*, Prasojo Pribadi (b), Dhuta Sukmarani (c)
(a*), (b) Department Pharmacy, Faculty of Health Sciences, University of Muhammadiyah Magelang
(c) Department Elementary School Teacher Education, University of Muhammadiyah Magelang
Abstract
Diabetes mellitus (DM) is a group of diseases characterized by high glucose levels in the blood resulting from a failure in insulin production or insulin action, or both. The specialty of Acanthus ilicifolius compared with other species when used for antidiabetic drugs is A. ilicifolius contains other secondary metabolites that are also good for health. This study aims to determine the effect of Jeruju leaf extract (A. illficolius) on the decrease of fasting blood glucose levels of rats and to know the most effective dose of A. ilcifolius extract on the reduction of fasting blood glucose levels of rats.This type of research is an experimental study of biomedical research design. The stages of this study consisted of sample preparation, identification of A. ilcifolius plant, leaf extraction of A. ilcifolius, qualitative analysis of saponin and tannin using thin layer chromatography method. Ethanol extract of A. ilcifolius with various doses, antidiabetic test in rats induced streptozotocin with categorized 15 animal samples into two control groups and three treatment groups and measured blood glucose level, followed by data analysis using ANOVA.The lowest activity occurred in negative control group, increased at dose 500 mg/kg, positive control and dose 250 mg/kg while the highest occurred in dose group 125 mg/kg. The result of statistic test with the parameter of decrease of fasting blood glucose level of the male rat of Wistar strain, in a group of jeruju leaf extract with dose 125 mg/kg and 250 mg/kg showed the significantly different result with a negative control group. Jeruju leaf extract with dose 125 mg/kg and 250 mg/kg have antidiabetic activity.
Keywords: Extract, Jeruju Leaf, Antidiabetic
Topic: Pharmacology